CytoDyn Inc.’s Vyrologix (leronlimab-Vyrologix) shows impressive results in critically ill COVID-19 patients

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CytoDyn Inc., a late-stage biotechnology company developing CCR5 inhibiting drug leronlimab- Vyrologix, showed impressive results in improving the immune function of critically ill COVID-19 patients in the United States.

Leronlimab- Vyrologix is a humanized monoclonal antibody drug used to treat HIV patients. The drug is a C-C chemokine receptor type 5 (CCR5) antagonist that protects healthy T cells from viral infection. The CCR5 receptor plays a crucial role in modulating immune cell trafficking to sites of inflammation.[1] Because of the drug’s ability to mitigate the cytokine storm which is common in COVID-19 fatalities,[2] it has become the basis for its study as a potential COVID-19 treatment.[3]

Leronlimab- Vyrologix appears to be a powerful treatment with hardly any drug related serious adverse events. CytoDyn’s recent treatment of patients under eIND (Emergency Investigational New Drug) with leronlimab for COVID-19 infection have shown impressive results as the drug reduced the plasma viral load and restored the immune function by day 7.5, [4]

CytoDyn has already completed its Phase 2 clinical trial for COVID-19, a double-blinded, randomized clinical trial for mild-to-moderate COVID-19 patients in the U.S. The company has also recently announced that they have completed the enrollment of 394 patients in its Phase 2b/3 randomized clinical trial for the severe-to-critically ill COVID-19 population.

Cytodyn has appointed Chiral Pharma, a subsidiary of New Marketlink Pharmaceutical Corporation (NMPC) as its authorized partner for the distribution of Leronlimab-Vyrologix to the Philippines subject to registration approval of Philippine Food and Drug Administration. Through the partnership, the companies are working to register Leronlimab under a licensed physician’s request for Compassionate Special Permit (CSP). It is the desire of Cytodyn and Chiral Pharma to make Leronlimab immediately available to patients with Covid-19.


[1] https://ghr.nlm.nih.gov/gene/CCR5


[2] https://www.webmd.com/lung/news/20200417/cytokine-storms-may-be-fueling-some-covid-deaths


[3] https://www.cytodyn.com/newsroom/press-releases/detail/399/leronlimab-used-in-seven-patients-with-severe-covid-19


[4] https://www.cytodyn.com/newsroom/press-releases/detail/452/impressive-results-from-cytodyns-phase-2-covid-19-trial

Tim Yap and his birthday party in Baguio city amidst the pandemic

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Media personality Tim Yap on Baguio event:

"I wanted to assure the public that we really followed all the LGU protocols bago kami umakyat ng Baguio. Alam po natin na ang Baguio is napaka-strict sa kanilang protocols and they will not allow anyone na umakyat ng Baguio na positive.

Lahat ng mga tao, bago umakyat ng tao, kailangan maka-secure ng negative na test. We ensured all the protocols were in place. Itong mga kasama ko, mga kaibigan ko, were also tested negative.

Lahat ng mga tao, mayroon silang mga mask. That time papunta na yung mga tao sa buffet table. Pagkatapos noon, kakain na sila so tinanggal nila maskara nila. Pagkatapos noon, pumasok yung mga dancers na mag-community dancing so hindi nila nasuot mask nila na sumayaw sila.

Ako po yung nag-organize noon. Ang pakay po noon is to promote Baguio as a destination parang local tourism. Sa akin, yun ang hangarin ko talaga. Para mag-push ng local tourism. Kung makikita mo social media ko, lahat talaga yun ang ginagawa ko for the past few months.

We made sure that we secured all necessary permits para matuloy ito dahil ang talagang goal namin, ang aim namin is to help restart the economy, reopen the economy at ma-promote ang local tourism.

I am fully cooperative po sa atin gobyerno at sa ating community kung ano kailangan gawin, nandito ako para mag-cooperate.

It was never my intention to offend anyone. I would never do anything na makaka-endanger kahit sinuman. We are all responsible citizens of this country and all we want to do is really is to help restart the economy and the push for local tourism."

Tim Yap missed all the points. *hyperventilates in ‘SANAOL PRIVILEGED’* 

Cordillera region is going to be on a lockdown on Feb 1-15 because of the new COVID variant tapos makikita ko sa trending topics yung party ni Tim Yap.

This is why I have too little respect for some tourists who visit our region. They disrespect our hospitality.

The cheek, the nerve, the gall, the audacity and the gumption of Tim Yap to use local tourism as an excuse for the insensitivity and  callousness.

Tim Yap is a perfect example on how the privileged people never understand how hard this pandemic is to the rest of the world! 

What I learned today: 'Pag mahirap ang nag-party - pasaway. 

'Pag mayayaman, promoting tourism. 

Baguio needs promoting as tourist destination? I don't think so. Also, who gets Tim Yap as influencer these days? The oldies of tourism who remember him from his Embassy days?

Tim Yap using the lame excuse of “promoting” Baguio and “boosting” its local tourism. In this time of the pandemic? 

Baguio doesn't need someone like Tim Yap and friends to promote tourism, especially if they can't even show how to be a responsible tourists. 

Tim Yap's brand of confidence to think that Baguio needs him to place the town on the map. LGU strategy of inviting him to throw a birthday party for his friends is so effective. Maybe advertise lots at the cemetery so when you visit Baguio you can stay forever. 

Taking COVID tests doesn’t mean you’re allowed to violate protocols.

And they think “negative” results from swab tests or other tests “shield them from contracting the virus somehow or at least through the duration of their party. Vaccine po yun!

All sorts of excuses.   Clearly it was not just during the “buffet” that they were not wearing masks.

Granted they tested negative. is Baguio zero covid cases now? What if it's the other way around & sila yung nahawa from an infected na baguio resident? Is it really that worth it ang magpa "party" in this time of pandemic?

Assuming na negative sila, allowed ang ganoong kadaming tao sa event? Walang nagsuot ng face mask or shield? Allowed yun sa Baguio?  Walang protocol  ang management sa guests?

Doesn't mean if you do a COVID-19 test and turn out negative, you can just party like this and disregard health protocols. You can safely gather but not like this which reeks of privilege and carelessness. Tim Yap and influencer friends are clearly another *breed*

The DOT Cordillera Administrative Region earlier launched a probe into the reported "party" organized by Yap at The Manor in Baguio City.  A Notice to Explain has already been issued to the establishment.

Unfortunately, either because of being largely Catholic, or an innate desire to be middle/upper class, we Filipinos have a tendency to give celebrities/politicians/anyone popular or powerful enough, a free pass to almost anything.

Alam nyo kung ano ang kalokohan? Baguio residents sacrificed not to visit family & relatives during the holidays dahil bawal ang gathering, but some "privileged" were busy partying somewhere in Baguio. 

This was done in poor taste, very insenstive sa part ni Tim Yap. When people in Baguio are struggling because of another quarantine, we’ll hear this news. Nakaka******* lang!

Kaya di mapagalitan ni mayor ang nangyaring party, kasi nga... kasama si mayor... 

So ironic that Mayor Magalong was the one that announced CAR to be placed under GCQ yet he was there at Tim Yap's birthday party.

Dear Cat Arambulo, are you also going to ask why don't these motherfuckers stay at home?

- Tim Yap

- Apples Aberin

- KC Concepcion

- Raymond Gutierrez

How about we fine people for violating social distancing restrictions & make it proportional to their income.

Don't penalise the poor who are trying to make ends meet during the pandemic, but charge reckless rich people like Mond Gutierrez & Tim Yap MILLIONS for what they did.

Siguro nakakainis lang din na people from La Trinidad and other neighbors of Baguio have to undergo strict health protocols for their livelihood but I guess Tim Yap can have his birthday party with all his guests.

Yep, Tim Yap was a fuckup for his Baguio party. But didn't Harry Roque go there too while Cagayan and Isabela were submerged in floodwater? Let's not forget about that other bitch. Nail them both.

Best Spider Solitaire App Games Available on Mobile

Wazzup Pilipinas!


You carry your mobile almost everywhere you go. It is a great way to kill some time and enjoy some mobile games when you are free. If you are unsure of what games to play, why not check out these best Spider Solitaire app games available on mobile.

We picked Spider Solitaire Masters as the best overall for its great gameplay and straightforward interface. Plus, the app has great features like an undo button and an offline mode.

If you want to know about the other great games you can enjoy with many different features, keep on reading.

3 Best Spider Solitaire App Games Available on Mobile

1. Spider Solitaire Masters

Spider Solitaire Masters one-stop shop to enjoy Spider Solitaire, the classic way. It boasts a very easy to use interface and keeps distractions to a minimum. This app is also great fun for someone who is just starting playing Spider Solitaire thanks to its undo and hint feature.

You have the option to draw either 1 card at a time or 3 cards to make things more challenging and fun. For the iOS version there is also a Vegas style gameplay you can enjoy too! Plus, there are also live tournaments where you can participate in the iOS version.

Why Download it?

· Minimal interface helps you focus on the game

· Undo and hint buttons

· Works without internet after downloading spidersolitairemasters.net



2. Spider Solitaire Cooking Tower

Spider Solitaire Cooking Tower takes a different approach to the popular Spider Solitaire formula. It mixes up a restaurant game and a Spider Solitaire game into one fun little app. The game will immediately impress you with its sharp and colorful graphics.

You might be asking how the app combines two different concepts. Sticky Hands Inc took the core concept of Spider Solitaire and made it into something new and fun. The core concept of the game is the same as any Spider Solitaire game. You need to create piles of four suits starting from Ace to King.

The genius twist here is every time you make a correct move; the game will reward you with a point. These points will unlock different menu items for your restaurant. That is not all though.

The biggest reward is upon winning the Play Solitaire Masters Card Games Online . When you win a game of Spider Solitaire, it unlocks a tower of restaurants. The more you win the higher the tower climbs. It is absolutely a joy to play and a refreshing new take on the classic Spider Solitaire app mobile game.

Why Download it?

· Colorful graphics

· The new concept makes it a refreshing game to play

· Fun game mechanics like combos and card collection



3. Classic Spider Solitaire Klondike

Classic Spider Solitaire Klondike is your one-stop shop to enjoy Spider Solitaire, the classic way. It boasts a very easy to use interface and keeps distractions to a minimum. This app is also great fun for someone who is just starting playing Spider Solitaire thanks to its undo feature.

The app’s install size is quite small as well. So, it should not take much space on your phone. Simply whip out your phone and start playing. The complete offline mode ensures you do not need a constant internet connection to enjoy the game.

The rules are simple. Build separate piles of each suit from Ace to Kind. It is easy and most importantly, fun to play.



Why Download it?

· Easy to play

· Great graphics

· No internet connection required



Conclusion

Any of these three best Spider Solitaire app games available on mobile are a perfect way to relax and play some games on your phone without much hassle. If you are going to be on your phone anyway, why not make the most of the free time.